Uce a complex pattern of clinical and toxic effects such as coagulation disorders, hemorrhage and necrosis [1-10]. Some of venom components act at various stages of the coagulation cascade. These components perform antagonistic functions, whilst some of them act synergistically. Therefore, the venom toxicity cannot be attributed to only one component [11]. However, most venom components produce beneficial effects when they act alone [12]. Snake venom also contains non-protein components including citrate,?2013 Ch ifi and Laraba-Djebari; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction 2-Bromo-1,3-difluoro-4-nitrobenzene in any medium, provided the original work is properly cited.Ch ifi and Laraba-Djebari Journal of Venomous Animals and Toxins including Tropical Diseases 2013, 19:11 http://www.jvat.org/content/19/1/Page 2 ofmetal ions, carbohydrates, nucleotides as well as low concentrations of free amino acids and lipids [13-15]. Phospholipases A2 (PLA2s) represent more than 10 of the dry weight of the snake venoms from which they are isolated. PLA2s isolated from Viperidae venoms consist of 125?30 amino acid residues cross-linked by seven disulfide bonds which confer stability on the molecule and 3-Amino-1H-indazole-4-carbonitrile are calcium-dependant [16]. In addition to their hydrolytic activity, PLA2s may display many other activities, such as edematous, neurotoxic, cardiotoxic, hemolytic, convulsive, antiplatelet, antitumoral and anticoagulant properties. Based on their anticoagulant activity, PLA2s can be clinically useful against thrombotic diseases and for the diagnosis and treatment of hemostatic disorders [17]. The anticoagulant activity is due to their ability to inhibit platelet aggregation through factor Xa (FXa) blockade. Based on their direct involvement in the hemostatic cascade, PLA2 could also be used as tools or biomarkers in blood diseases. Metalloproteinases found in Viperidae venoms may cause local hemorrhaging following accidental or experimental intradermal or subcutaneous injection of venom [18]. Some of them are known to display fibrino (geno)lytic activity. Fibrino(geno)lytic metalloproteinases dissolve fibrin clots and prevent clot formation by hydrolyzing fibrinogen, thus enhancing the toxic effect of hemorrhagic metalloproteinases, giving rise to pathological bleeding [19]. However, similar to PLA2s, metalloproteinases could be clinically useful against thrombotic diseases thanks to their potential use in laboratory tests or as therapeutic agents [20,21]. PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/17591728 These proteinases may be useful for investigating the mechanisms of blood coagulation and platelet aggregation [11,12]. 54718-39-7 In Stock,39065-95-7 custom synthesis,2454396-80-4 Purity ¡۱00%,503614-91-3 chemscene,1088994-18-6 web,2168499-15-6 Data Sheet,2137792-51-7 Formula,52222-73-8 Description,944401-77-8 Purity ¡۱06%,142266-62-4 Data Sheet,55860-35-0 Documentation,10325-70-9 Data Sheet,15450-69-8 web,73246-45-4 chemscene,945244-29-1 In Stock,13323-45-0 chemscene,89003-95-2 Technical Information,784-71-4 manufacturer,78775-11-8 Formula,25563-04-6 Technical Information,17145-91-4 Order Online,1416013-62-1 manufacturer,20955-94-6 Purity ¡۱20%,57196-62-0 Formula,20357-21-5 Technical Information,10542-80-0 Documentation,32305-98-9 manufacturer,7209-11-2 Technical Information,90259-31-7 supplier,56962-10-8 custom synthesis,100523-84-0 chemscene,574007-66-2 NMR,926922-40-9 Documentation,57097-81-1 Technical Information,124276-67-1 Building Blocks,869970-25-2 Description,376584-63-3 Order Online,40235-68-5 manufacturer,96034-64-9 Description,849052-26-2 chemscene,49764-63-8 Data Sheet,685517-71-9 Description,142946-79-0 manufacturer,194-59-2 manufacturer,79424-03-6 custom synthesis,3307-41-3 Building Blocks,790667-49-1 chemscene,1073-39-8 chemscene,145038-49-9 HPLC,201940-08-1 Technical Information,666832-71-9 Technical Information,219873-06-0 Description,57645-53-1 site,58640-01-0 Formula,37901-92-1 chemscene,1162120-35-5 custom synthesis,612501-45-8 Building Blocks,761440-16-8 Technical Information,689291-89-2 Description,113231-05-3 Description,42779-56-6 Documentation,866807-26-3 Description,939410-87-4 Data Sheet,169869-90-3 Data Sheet,76137-53-6 manufacturer,402-50-6 Technical Information,1889077-30-8 Description,253315-11-6 Technical Information,1221448-62-9 Documentation,886501-15-1 web,875781-43-4 Data Sheet,5521-31-3 Data Sheet,2278357-65-4 Technical Information,81721-86-0 Description,14295-52-4 Order Online,191604-81-6 Description,328086-60-8 web,29046-78-4 site,6783-05-7 site,67460-86-0 Documentation,108549-23-1 Description,363166-11-4 chemscene,12135-22-7 Data Sheet,1672665-55-2 site,63600-35-1 Data Sheet,40153-45-5 Technical Information,24566-79-8 Order Online,886365-02-2 chemscene,16545-68-9 chemscene,73799-64-1 manufacturer,58546-89-7 Documentation,106291-80-9 Data Sheet,1137869-92-1 chemscene,50741-70-3 Formula,213764-25-1 custom synthesis,65326-33-2 site,1573-91-7 manufacturer,50413-30-4 Description,857530-80-4 Technical Information,177284-56-9 custom synthesis,904326-92-7 HPLC,33689-29-1 Documentation,153747-97-8 Purity ¡۱75%,59854-12-5 Order Online,2569698-42-4 supplier,28824-91-1 Documentation,1194-18-9 Technical Information,151049-87-5 chemscene,3999-55-1 manufacturer,800402-06-6 supplier,10597-60-1 MS,16079-88-2 supplier,79080-39-0 manufacturer,106778-43-2 supplier,887144-94-7 supplier,197223-39-5 supplier,1002309-52-5 site,1236861-75-8 manufacturer,1107627-02-0 Purity ¡۱91%,72607-53-5 web,1345469-26-2 Description,98905-05-6 web,60239-18-1 Documentation,406913-93-7 Building Blocks,51043-72-2 Technical Information,13885-13-7 supplier,63024-50-0 web,2840-44-0 Description,4956-05-2 supplier,83647-40-9 Order Online,89985-87-5 Building Blocks,288-42-6 Order Online,120157-95-1 Description,64700-65-8 Description,1205-58-9 Technical Information,1140908-89-9 Order Online,405939-39-1 HPLC,103440-70-6 chemscene,873055-55-1 In Stock,52798-01-3 Formula,2533-67-7 Description,1026089-09-7 Documentation,3441-01-8 Description,1072951-50-8 chemscene,2968-13-0 web,160590-40-9 chemscene,5836-54-4 Documentation,13831-03-3 Documentation,10328-92-4 MS,52378-64-0 site,548-93-6 site,1037834-62-0 NMR,30169-25-6 Purity ¡۲25%,59260-76-3 Order Online,1798-85-2 web,142356-33-0 Purity ¡۲28%,850429-64-0 site,681807-59-0 Formula,2055761-19-6 site,766-46-1 custom synthesis,58196-33-1 custom synthesis,391624-46-7 web,138373-85-0 Description,438631-77-7 Documentation,135716-08-4 Data Sheet,99329-85-8 site,4233-33-4 web,13965-03-2 web,3816-62-4 Description,75833-38-4 chemscene,54258-41-2 Technical Information,146394-99-2 manufacturer,14062-05-6 Data Sheet,2031242-60-9 Building Blocks,68797-61-5 custom synthesis,55704-60-4 MS,942919-26-8 custom synthesis,406470-63-1 site,43192-34-3 web,4664-08-8 site,1209167-05-4 custom synthesis,403-18-9 Description,22262-60-8 Technical Information,1126-44-9 web,774234-25-2 Formula,507472-25-5 supplier,117342-20-8 Building Blocks,878376-35-3 HPLC,107504-07-4 Technical Information,45206-91-5 Documentation,2133-07-5 Description,90633-29-7 site,141699-57-2 supplier,741721-51-7 manufacturer,83947-59-5 In Stock,2605-68-7 web,500357-40-4 Formula,1119505-52-0 web,188447-91-8 Purity ¡۲71%,260430-93-1 Technical Information,56961-78-5 Technical Information,199110-64-0 custom synthesis,13482-23-0 Formula,1345091-18-0 Data Sheet,133261-06-0 Description,1072150-21-0 Order Online,2196-99-8 site,6999-03-7 supplier,913836-22-3 custom synthesis,933469-83-1 Description,30830-27-4 Building Blocks,16689-35-3 Documentation,121138-01-0 Description,451459-17-9 manufacturer,1109-15-5 Documentation,79055-60-0 Documentation,39891-04-8 Documentation,163619-04-3 manufacturer,66346-87-0 HPLC,128-63-2 supplier,289038-22-8 web,28314-83-2 Description,208173-21-1 Formula,50606-31-0 supplier,1374264-44-4 Data Sheet,944900-49-6 web,1122-43-6 HPLC,892570-95-5 Documentation,109704-53-2 manufacturer,51364-51-3 Data Sheet,195202-09-6 supplier,827-33-8 custom synthesis,1829-32-9 web,223259-62-9 Technical Information,124289-21-0 site,1415564-71-4 In Stock,406232-79-9 Data Sheet,5194-32-1 Order Online,18720-35-9 manufacturer,36748-89-7 chemscene,24346-56-3 manufacturer,656-46-2 Documentation,2156-04-9 Documentation,5870-38-2 Purity ¡۳16%,7597-56-0 Technical Information,73365-02-3 Data Sheet,89581-38-4 manufacturer,39513-26-3 manufacturer,22532-61-2 Documentation,51939-71-0 Data Sheet,33398-79-7 chemscene,3177-20-6 Technical Information,705-28-2 Technical Information,22724-81-8 In Stock,15484-46-5 Technical Information,223259-63-0 Building Blocks,1314538-55-0 Formula,5994-87-6 supplier,404-24-0 supplier,4298-52-6 web,95058-81-4 manufacturer,14160-91-9 Formula,1013883-02-7 supplier,175205-81-9 Data Sheet,79537-70-5 HPLC,935-30-8 site,731011-86-2 Technical Information,144120-54-7 supplier,199174-24-8 Data Sheet,2417920-98-8 Formula,41428-22-2 NMR,150629-67-7 Documentation,269410-24-4 Description,124755-24-4 web,20744-39-2 In Stock,74003-55-7 Data Sheet,567-61-3 Description,5551-11-1 Purity ¡۵75%,1044707-17-6 Order Online,40004-08-8 site,14446-24-3 Data Sheet,38707-70-9 MS,703-91-3 chemscene,1099029-85-2 Building Blocks,75416-51-2 Formula,62247-22-7 web,284492-23-5 Data Sheet,288148-34-5 Purity ¡۵85%,252932-49-3 Documentation,5406-18-8 chemscene,35979-69-2 site,30725-00-9 Technical Information,120116-88-3 web,16063-69-7 custom synthesis,14548-51-7 Building Blocks,103260-65-7 manufacturer,94333-62-7 Technical Information,365564-05-2 In Stock,50488-34-1 site,1208081-25-7 Documentation,1206675-01-5 chemscene,133803-81-3 web,14544-47-9 Data Sheet,532-12-7 custom synthesis,29509-06-6 Description,34403-48-0 Documentation,351410-62-3 Technical Information,53312-77-9 site,36805-97-7 Formula,6030-36-0 Building Blocks,59279-58-2 Formula,39773-47-2 MS,1805818-57-8 Order Online,1251032-65-1 Formula,6140-65-4 site,67963-68-2 custom synthesis,164334-69-4 chemscene,191348-14-8 Description,1234616-13-7 Formula,1185100-09-7 web,13288-57-8 supplier,1532-84-9 supplier,41252-98-6 HPLC,1137869-93-2 Documentation,28148-04-1 Formula,2589-12-0 custom synthesis,13999-39-8 chemscene,947-91-1 chemscene,74420-02-3 Documentation,17996-12-2 Data Sheet,117324-58-0 Data Sheet,13991-08-7 In Stock,500556-91-2 Formula,17997-47-6 Technical Information,607373-83-1 Purity ¡۴07%,1206979-33-0 Formula,28945-98-4 manufacturer,104-11-0 web,5462-71-5 web,1147557-97-8 manufacturer,111409-79-1 chemscene,10165-86-3 Documentation,50868-73-0 custom synthesis,934-98-5 MS,40353-34-2 site,1683-85-8 supplier,3189-22-8 custom synthesis,329976-73-0 Building Blocks,188813-04-9 NMR,107259-05-2 Description,1196156-59-8 custom synthesis,135-67-1 Formula,142070-24-4 In Stock,2172466-50-9 chemscene,145508-94-7 supplier,37418-88-5 Documentation,864293-44-7 supplier,190906-92-4 site,10049-08-8 Description,936250-20-3 Purity ¡۴32%,34699-28-0 supplier,161417-28-3 Data Sheet,29836-26-8 supplier,2945-08-6 Formula,1122-10-7 Technical Information,95464-05-4 In Stock,89641-18-9 chemscene,1420800-30-1 Documentation,4295-06-1 site,73505-48-3 custom synthesis,1196153-47-5 site,66176-17-8 Technical Information,97456-81-0 web,112641-20-0 manufacturer,51644-96-3 web,78560-45-9 Technical Information,321970-60-9 Documentation,1225049-48-8 chemscene,131341-86-1 site,38186-51-5 MS,1236862-38-6 Technical Information,143655-70-3 web,82769-76-4 Documentation,446-29-7 custom synthesis,885520-35-4 Purity ¡۴57%,53207-00-4 custom synthesis,1167055-92-6 In Stock,62803-47-8 HPLC,4694-91-1 Documentation,3975-77-7 chemscene,845866-85-5 web,1076-96-6 Documentation,59379-02-1 Description,252989-57-4 Purity ¡۴66%,160590-36-3 site,155975-19-2 supplier,884495-13-0 NMR,29027-17-6 HPLC,1172052-59-3 Formula,335104-84-2 Documentation,170098-98-3 Purity ¡۴73%,248274-16-0 custom synthesis,23235-01-0 MS,120155-43-3 Technical Information,685109-10-8 chemscene,193290-80-1 custom synthesis,74346-19-3 Description,4971-18-0 manufacturer,10602-00-3 Technical Information,108612-54-0 Data Sheet,913835-76-4 Formula,176707-77-0 web,6287-82-7 manufacturer,193290-19-6 chemscene,194543-22-1 Technical Information,21962-45-8 Data Sheet,99027-90-4 Data Sheet,884494-49-9 Documentation,101251-09-6 chemscene,392331-89-4 manufacturer,81270-37-3 Description,2055119-43-0 Order Online,131328-27-3 Description,688810-12-0 site,717843-51-1 chemscene,1628263-61-5 manufacturer,34301-54-7 Description,2350-89-2 Formula,503-66-2 web,85920-63-4 NMR,19256-31-6 MS,53439-88-6 HPLC,590371-58-7 Documentation,10167-97-2 Description,677728-92-6 chemscene,96517-92-9 web,63697-96-1 site,1172713-86-8 HPLC,13991-36-1 HPLC,3027-05-2 site,2835-97-4 supplier,3298-16-6 custom synthesis,7648-30-8 chemscene,83265-53-6 Documentation,1093860-48-0 custom synthesis,80657-57-4 Description,81090-53-1 Data Sheet,3819-88-3 web,1092443-98-5 Description,140645-24-5 Building Blocks,57190-17-7 chemscene,811-93-8 Technical Information,54745-74-3 supplier,14190-59-1 Documentation,2879-42-7 Formula,162607-19-4 supplier,39639-99-1 Technical Information,198835-04-0 manufacturer,144120-53-6 site,1886994-07-5 Purity ¡۵32%,127828-22-2 supplier,89043-32-3 manufacturer,57500-81-9 site,2152673-80-6 Documentation,111627-46-4 Description,234108-73-7 supplier,23082-30-6 chemscene,361-72-8 Technical Information,148-79-8 supplier,7651-82-3 HPLC,22245-84-7 Technical Information,39069-02-8 Technical Information,851386-31-7 Description,213771-32-5 custom synthesis,6018-56-0 Description,2713-29-3 Description,4293-57-6 Documentation,69626-39-7 In Stock,77278-70-7 Data Sheet,865815-09-4 custom synthesis,39512-59-9 manufacturer,130047-19-7 Documentation,885223-65-4 Formula,1394003-86-1 In Stock,876919-08-3 NMR,944805-63-4 Data Sheet,24630-67-9 web,92-89-7 manufacturer,131747-41-6 Data Sheet,329794-28-7 Description,957062-84-9 Documentation,361550-43-8 Formula,95408-45-0 Technical Information,50-23-7 HPLC,57489-77-7 chemscene,790667-43-5 custom synthesis,7022-37-9 Documentation,3398-22-9 Building Blocks,3093-97-8 NMR,1075242-43-1 Technical Information,363-58-6 manufacturer,144701-24-6 HPLC,67198-21-4 Documentation,53985-49-2 chemscene,32936-76-8 Purity ¡۶02%,1261468-33-0 Formula,121859-57-2 Documentation,886762-71-6 Technical Information,173405-78-2 In Stock,78018-17-4 custom synthesis,4265-16-1 Documentation,62458-96-2 Data Sheet,155797-02-7 Description,157141-27-0 Description,17396-35-9 web,162155-38-6 Building Blocks,16292-95-8 site,623580-02-9 chemscene,17827-60-0 Building Blocks,56842-95-6 In Stock,42097-42-7 supplier,16502-01-5 manufacturer,1154741-20-4 chemscene,1394040-59-5 site,126689-00-7 NMR,49674-16-0 custom synthesis,1427082-83-4 Building Blocks,1003709-39-4 site,32337-96-5 NMR,75680-92-1 Purity ¡۸27%,84575-27-9 In Stock,76315-33-8 web,4864-01-1 NMR,136725-55-8 custom synthesis,17321-29-8 manufacturer,1020174-04-2 chemscene,1394042-40-0 Description,159277-47-1 Purity ¡۸35%,27825-20-3 Technical Information,375853-98-8 NMR,934758-27-7 Order Online,3712-40-1 Data Sheet,282735-66-4 manufacturer,55864-87-4 Technical Information,713141-12-9 manufacturer,52462-29-0 In Stock,19064-65-4 Documentation,63485-50-7 web,90564-77-5 chemscene,98436-83-0 Documentation,59760-01-9 Data Sheet,305790-48-1 manufacturer,1016234-87-9 site,175278-30-5 site,175276-74-1 web,957034-45-6 HPLC,25813-25-6 Technical Information,139551-74-9 Description,151945-84-5 Building Blocks,27298-98-2 custom synthesis,19788-36-4 Purity ¡۶33%,25016-02-8 chemscene,17376-63-5 chemscene,21382-98-9 web,762260-64-0 site,148639-07-0 Technical Information,651027-01-9 HPLC,144599-95-1 Formula,19112-35-7 Description,17345-77-6 Formula,91229-86-6 site,26893-68-5 web,1864073-05-1 Building Blocks,1128-61-6 web,938043-30-2 Technical Information,1627924-18-8 Description,1229603-46-6 Order Online,936841-70-2 manufacturer,52670-38-9 chemscene,867366-91-4 Description,6940-57-4 chemscene,1703-61-3 Data Sheet,100421-52-1 Building Blocks,123973-22-8 Purity ¡۶56%,95201-93-7 Formula,198561-07-8 Description,5400-79-3 Description,19005-93-7 manufacturer,939400-34-7 NMR,120740-08-1 Technical Information,3096-81-9 site,893441-85-5 site,35511-15-0 supplier,34914-36-8 site,178876-83-0 Documentation,72287-26-4 manufacturer,16681-56-4 Data Sheet,160233-76-1 web,2040-14-4 web,41059-02-3 site,1219956-23-6 supplier,1269232-95-2 Documentation,204376-48-7 supplier,1776-37-0 site,1247924-89-5 manufacturer,116557-46-1 custom synthesis,120121-01-9 Technical Information,84547-62-6 site,20442-79-9 Formula,90-52-8 chemscene,23012-13-7 manufacturer,2097971-11-2 HPLC,116286-81-8 chemscene,105-84-0 Documentation,20327-23-5 Formula,112776-84-8 Formula,5470-65-5 Building Blocks,21548-73-2 Formula,1005612-69-0 Documentation,1049756-13-9 Description,74173-58-3 Technical Information,14898-67-0 In Stock,873924-08-4 Description,5617-70-9 Order Online,134098-70-7 Documentation,73208-82-9 custom synthesis,40319-63-9 web,1352244-77-9 Documentation,505084-59-3 Data Sheet,72080-83-2 Description,19271-24-0 web,256417-10-4 site,19282-44-1 Formula,251115-21-6 Documentation,614-98-2 Technical Information,108915-04-4 Technical Information,648921-37-3 HPLC,1001020-14-9 manufacturer,885267-36-7 In Stock,70708-33-7 In Stock,6790-09-6 Documentation,18370-95-1 supplier,2221-00-3 custom synthesis,690632-39-4 Documentation,62366-58-9 Technical Information,2353-33-5 custom synthesis,10201-71-5 supplier,160357-94-8 Description,536-25-4 Building Blocks,533-30-2 manufacturer,151103-08-1 custom synthesis,7770-45-8 chemscene,1179042-36-4 In Stock,82475-76-1 Documentation,1384433-82-2 Documentation,1170249-44-1 manufacturer,42163-27-9 custom synthesis,18531-95-8 custom synthesis,7170-01-6 Description,51586-21-1 Documentation,120100-15-4 MS,3650-78-0 Building Blocks,211943-27-0 Technical Information,66200-70-2 manufacturer,1181458-90-1 Documentation,5394-13-8 Documentation,928664-98-6 Documentation,178033-78-8 Data Sheet,16605-99-5 chemscene,2270-59-9 web,144222-34-4 Documentation,16732-69-7 supplier,1219827-56-1 Documentation,24566-81-2 manufacturer,166815-96-9 NMR,1158319-57-3 Documentation,2621939-48-6 custom synthesis,1240518-54-0 Documentation,13047-01-3 Technical Information,2439-04-5 web,145691-59-4 Order Online,262433-22-7 In Stock,479622-36-1 MS,5579-66-8 Documentation,24310-15-4 Technical Information,6315-60-2 In Stock,95756-62-0 Formula,255724-71-1 Technical Information,156017-42-4 web,7470-38-4 Data Sheet,2380-84-9 manufacturer,159610-89-6 Technical Information,103977-78-2 Formula,18595-17-0 HPLC,1048960-62-8 MS,3945-85-5 Technical Information,828298-11-9 supplier,2475-81-2 Description,223137-87-9 site,1159908-24-3 Formula,1190315-72-0 Technical Information,799773-82-3 web,91978-81-3 NMR,129012-04-0 HPLC,935-14-8 Data Sheet,277756-45-3 chemscene,13362-78-2 Description,19171-19-8 Data Sheet,7238-61-1 Formula,115306-75-7 web,68500-37-8 Documentation,6942-58-1 Purity ¡۷84%,1094070-77-5 Order Online,75705-21-4 Formula,281192-91-4 Data Sheet,92933-47-6 MS,172899-78-4 Documentation,42826-42-6 Order Online,83728-40-9 In Stock,115994-87-1 Data Sheet,6854-07-5 Data Sheet,42881-66-3 supplier,114873-11-9 web,82972-28-9 manufacturer,932-35-4 web,20274-69-5 Technical Information,550363-85-4 Data Sheet,1030377-21-9 Technical Information,89584-24-7 Documentation,6921-22-8 manufacturer,136888-20-5 site,2003-10-3 web,5751-48-4 custom synthesis,59804-25-0 custom synthesis,889865-56-9 site,77128-72-4 site,234108-42-0 web,41070-35-3 Documentation,59608-97-8 Formula,177596-38-2 Documentation,1006348-65-7 Documentation,36745-93-4 supplier,886496-45-3 Formula,447464-03-1 Building Blocks,56267-48-2 Documentation,1497312-94-3 Building Blocks,139009-66-8 MS,20734-76-3 HPLC,35852-77-8 In Stock,37674-72-9 web,280774-03-0 web,25045-36-7 manufacturer,2044901-46-2 web,103-40-2 Documentation,4704-94-3 Technical Information,34631-53-3 Building Blocks,17205-02-6 Data Sheet,15448-77-8 Data Sheet,214210-21-6 Data Sheet,162894-76-0 web,373384-18-0 Building Blocks,285984-25-0 Building Blocks,2096331-76-7 NMR,1396680-55-9 Order Online,886886-04-0 supplier,1024583-33-2 custom synthesis,5959-52-4 Technical Information,1121-66-0 MS,657-24-9 Data Sheet,5198-88-9 chemscene,361476-01-9 Formula,1150617-92-7 Data Sheet,6267-02-3 web,14245-62-6 web,28562-68-7 chemscene,603965-77-1 Technical Information,19520-74-2 Description,2138-22-9 site,669050-70-8 supplier,1416881-52-1 Order Online,601-84-3 In Stock,517920-69-3 Formula,18791-99-6 supplier,14542-12-2 web,85462-59-5 HPLC,41574-91-8 Building Blocks,76543-27-6 manufacturer,828-94-4 Purity ¡۱085%,56962-11-9 chemscene,23077-43-2 Formula,590-97-6 Formula,1201-91-8 Data Sheet,72715-12-9 custom synthesis,887919-35-9 custom synthesis,26095-36-3 supplier,1227068-67-8 Technical Information,866633-25-2 Description,151159-28-3 chemscene,66522-66-5 Formula,3526-43-0 Formula,428-63-7 Purity ¡۸73%,93281-65-3 site,15029-36-4 custom synthesis,1824063-21-9 NMR,446299-81-6 Description,20776-55-0 Data Sheet,181365-26-4 Purity ¡۸79%,185985-40-4 Technical Information,125568-73-2 HPLC,33097-11-9 Documentation,53293-00-8 Data Sheet,946759-18-8 supplier,28165-45-9 Data Sheet,2789-25-5 manufacturer,1450662-30-2 chemscene,142356-34-1 NMR,1001499-95-1 custom synthesis,138957-91-2 HPLC,33228-45-4 Technical Information,214360-70-0 site,1057216-52-0 site,1801893-44-6 Data Sheet,334658-75-2 Order Online,1998-66-9 Technical Information,311-86-4 Description,6291-01-6 web,75884-70-7 NMR,1262397-12-5 site,41175-50-2 chemscene,402-12-0 Technical Information,927996-01-8 Technical Information,3970-68-1 Technical Information,113893-08-6 Description,461-98-3 Documentation,1522335-03-0 supplier,499983-13-0 In Stock,4064-06-6 Documentation,214342-63-9 Description,13669-42-6 Data Sheet,857061-44-0 Description,5744-80-9 supplier,275818-95-6 Data Sheet,1256803-11-8 site,254435-23-9 web,172215-91-7 Description,56745-01-8 MS,53218-26-1 web,185220-68-2 chemscene,6334-01-6 web,1455091-10-7 Building Blocks,1092693-73-6 Order Online,54231-33-3 manufacturer,374537-97-0 Description,104901-79-3 web,83647-43-2 Building Blocks,1159815-63-0 manufacturer,265981-13-3 supplier,27126-42-7 In Stock,68774-77-6 Technical Information,127972-00-3 custom synthesis,15513-48-1 custom synthesis,6587-24-2 Technical Information,37669-64-0 manufacturer,6813-38-3 custom synthesis,2092312-45-1 supplier,130309-37-4 web,69570-83-8 Technical Information,42058-59-3 web,174565-63-0 site,159858-21-6 Formula,63878-73-9 Data Sheet,30363-03-2 Technical Information,362670-06-2 custom synthesis,106719-44-2 Building Blocks,771-97-1 Documentation,381247-99-0 Technical Information,65868-63-5 manufacturer,63639-61-2 custom synthesis,885952-18-1 HPLC,88824-09-3 Order Online,117519-07-0 custom synthesis,365996-06-1 Documentation,25339-99-5 Data Sheet,352535-84-3 Documentation,124668-49-1 web,16265-11-5 site,187344-92-9 MS,5900-59-4 manufacturer,1185295-39-9 supplier,1343056-10-9 custom synthesis,14997-58-1 Technical Information,28562-61-0 supplier,2150-93-8 Technical Information,1296209-28-3 Formula,165727-45-7 supplier,1220028-20-5 chemscene,16097-60-2 HPLC,84153-82-2 Formula,87014-28-6 custom synthesis,1201643-59-5 Order Online,123926-62-5 Documentation,32993-05-8 Documentation,860296-12-4 Formula,400899-84-5 Technical Information,89976-27-2 manufacturer,599183-33-2 HPLC,7781-10-4 web,447-53-0 web,1735-89-3 custom synthesis,1447963-75-8 site,4815-29-6 Documentation,3788-56-5 manufacturer,916792-15-9 site,56131-46-5 manufacturer,882679-40-5 manufacturer,6602-33-1 supplier,1000414-38-9 custom synthesis,847818-55-7 Documentation,29176-55-4 chemscene,131747-63-2 Formula,194995-47-6 site,1214337-57-1 Building Blocks,221295-04-1 HPLC,762229-49-2 HPLC,870238-67-8 Documentation,112970-44-2 Description,163451-81-8 Data Sheet,256411-39-9 Documentation,1002334-12-4 Order Online,943152-94-1 site,25021-08-3 Technical Information,1240948-77-9 Technical Information,714951-87-8 MS,3539-97-7 site,3190-71-4 custom synthesis,219503-74-9 manufacturer,169243-86-1 site,51985-95-6 Formula,25181-50-4 Data Sheet,261715-71-3 Data Sheet,445-13-6 supplier,37688-96-3 manufacturer,934996-78-8 custom synthesis,597551-56-9 manufacturer,66131-68-8 Documentation,113206-03-4 web,820236-81-5 Technical Information,1260665-60-8 Documentation,2380-36-1 Technical Information,937599-94-5 Purity ¡۱022%,19008-71-0 NMR,1010120-55-4 chemscene,88048-43-5 Documentation,1352144-78-5 NMR,6665-97-0 Formula,192214-06-5 web,70416-53-4 NMR,99455-15-9 Order Online,60633-26-3 supplier,2103-49-3 manufacturer,84964-24-9 Technical Information,1567892-21-0 supplier,790184-33-7 web,1030012-30-6 custom synthesis,25566-00-1 supplier,6947-94-0 Description,91760-66-6 In Stock,696-40-2 custom synthesis,1410002-81-1 site,345954-83-8 supplier,32111-28-7 web,779-27-1 Documentation,4108-90-1 Technical Information,877-90-7 web,95715-87-0 Building Blocks,1210419-26-3 Documentation,174603-38-4 web,167479-13-2 MS,55750-48-6 site,5154-01-8 custom synthesis,66361-67-9 chemscene,106984-09-2 Data Sheet,306960-74-7 Description,89466-16-0 Formula,1185297-53-3 MS,2199-58-8 MS,1142400-61-0 Building Blocks,62456-34-2 NMR,5147-80-8 web,854107-53-2 Documentation,3034-48-8 site,412947-54-7 Technical Information,819058-34-9 Building Blocks,1049706-73-1 MS,697300-73-5 Technical Information,203787-91-1 Building Blocks,337904-92-4 custom synthesis,2589531-74-6 Technical Information,66207-23-6 site,501435-91-2 site addition to their beneficial effects, venom molecules are the cause of health problems after snake envenomation. Annually, more than 100,000 deaths are recorded worldwide, including 20,000 on African continent, while 400,000 victims retain severe and permanent functional sequelae [3]. Epidemiological data estimate envenomation cases at more than 5 million per year, with a mortality rate of 2.5 . In tropical Africa, Viperidae bites are responsible for 90 of envenomations [22]. Currently, the PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/8833965 only available specific treatment against viper envenomation is immunotherapy [23-26]. Indications for this therapy, its mode of administration and type of antibody preparation in the form of F (ab’)2 or Fab still need to be el.